Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.35 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453411 | 0.86 | SYK (0.39) | HIF1AMEN1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL22453230 | 0.86 | SERPINE1 (0.46) | SERPINE1NPC1HIF1AEPAS1DHODH | |
| SCHEMBL22453641 | 0.85 | DHODH (0.55) | SERPINE1NPC1HIF1AEPAS1DHODH | |
| SCHEMBL22452686 | 0.84 | KDM5A (0.50) | SERPINE1NPC1HIF1AEPAS1DHODH | |
| SCHEMBL22452486 | 0.81 | HIF1A (0.50) | SERPINE1NPC1HIF1AEPAS1MEN1 | |
| SCHEMBL22453415 | 0.81 | SERPINE1 (0.53) | SERPINE1NPC1HIF1AEPAS1MEN1 | |
| SCHEMBL22453267 | 0.81 | SERPINE1 (0.42) | SERPINE1NPC1HIF1AEPAS1DHODH | |
| SCHEMBL22452561 | 0.80 | SERPINE1 (0.44) | SERPINE1NPC1HIF1AEPAS1BCL6 | |
| SCHEMBL22453640 | 0.80 | DHODH (0.57) | SERPINE1NPC1HIF1AEPAS1DHODH | |
| SCHEMBL22453002 | 0.80 | DHODH (0.50) | SERPINE1NPC1HIF1AEPAS1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |