Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452693 | 0.86 | SERPINE1 (0.45) | HIF1ASMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL22453545 | 0.83 | HPGD (0.52) | HIF1ANPSR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL22453409 | 0.80 | HIF1A (0.49) | HIF1AEGFRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL22453416 | 0.78 | HIF1A (0.42) | HIF1ACNR2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL22452572 | 0.78 | MAPT (0.45) | HIF1ANPSR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL22453117 | 0.78 | CNR2 (0.53) | HIF1ACNR2NPSR1SMN1; SMN2MEN1 | |
| SCHEMBL22453142 | 0.77 | EPHX2 (0.40) | HIF1ACNR2SMN1; SMN2RAB9AHPGD | |
| SCHEMBL22452942 | 0.77 | HIF1A (0.41) | HIF1ACNR2NPSR1KMT2ALMNA | |
| SCHEMBL22453230 | 0.75 | SERPINE1 (0.46) | HIF1ASMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL22452964 | 0.73 | NPC1 (0.43) | EGFRSMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |