Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.53 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453693 | 0.90 | HIF1A (0.54) | HIF1AEPAS1PGRMEN1KMT2A | |
| SCHEMBL22453850 | 0.86 | MEN1 (0.45) | HIF1AEPAS1PGRMEN1KMT2A | |
| SCHEMBL22452760 | 0.84 | HIF1A (0.67) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL22453626 | 0.84 | SERPINE1 (0.65) | HIF1AEPAS1SERPINE1PGRMEN1 | |
| SCHEMBL22453341 | 0.82 | HIF1A (0.49) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL22453497 | 0.82 | SERPINE1 (0.57) | HIF1AEPAS1SERPINE1PGRMEN1 | |
| SCHEMBL22452527 | 0.82 | SERPINE1 (0.57) | HIF1AEPAS1SERPINE1PGRMEN1 | |
| SCHEMBL2746775 | 0.81 | KDM4E (0.50) | HIF1AEPAS1PGRMEN1KMT2A | |
| SCHEMBL22452688 | 0.79 | HIF1A (0.46) | HIF1AEPAS1SERPINE1PGRCYP2C9 | |
| SCHEMBL22452488 | 0.78 | SERPINE1 (0.64) | HIF1AEPAS1SERPINE1PGRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |