Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | P2RY10 | O00398 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453806 | 0.83 | HIF1A (0.51) | HIF1AEPAS1KDM4ENPC1EPHX2 | |
| SCHEMBL22452696 | 0.82 | HIF1A (0.53) | HIF1AEPAS1KDM4ENPC1EPHX2 | |
| SCHEMBL2746775 | 0.80 | KDM4E (0.50) | HIF1AEPAS1KDM4EEPHX2MEN1 | |
| SCHEMBL22453692 | 0.79 | NPC1 (0.41) | HIF1AEPAS1KDM4ENPC1EPHX2 | |
| SCHEMBL22453291 | 0.76 | SERPINE1 (0.52) | HIF1AEPAS1NPC1EPHX2CNR2 | |
| SCHEMBL22453693 | 0.73 | HIF1A (0.54) | HIF1AEPAS1NPC1EPHX2MEN1 | |
| SCHEMBL22452811 | 0.72 | HIF1A (0.52) | HIF1AEPAS1EPHX2MEN1KMT2A | |
| SCHEMBL22452760 | 0.70 | HIF1A (0.67) | HIF1AEPAS1NPC1MEN1KMT2A | |
| SCHEMBL2746811 | 0.70 | KDM4E (0.47) | HIF1AEPAS1KDM4EEPHX2MEN1 | |
| SCHEMBL31555348 | 0.69 | HIF1A (0.60) | HIF1AEPAS1KDM4ENPC1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |