Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.49 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.48 |
| ▸ | DHODH | Q02127 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453240 | 0.90 | DHODH (0.54) | HIF1AEPAS1SERPINE1DHODHMEN1 | |
| SCHEMBL22453543 | 0.90 | CNR2 (0.53) | HIF1AEPAS1MEN1KMT2AMAPT | |
| SCHEMBL22452767 | 0.88 | SERPINE1 (0.58) | HIF1AEPAS1SERPINE1DHODHMEN1 | |
| SCHEMBL22452768 | 0.85 | SERPINE1 (0.52) | HIF1AEPAS1SERPINE1DHODHMEN1 | |
| SCHEMBL22452809 | 0.85 | DHODH (0.54) | HIF1AEPAS1DHODHMEN1KMT2A | |
| SCHEMBL22453316 | 0.85 | DHODH (0.56) | HIF1ASERPINE1DHODHMEN1KMT2A | |
| SCHEMBL22452690 | 0.84 | SIRT2 (0.57) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL22452682 | 0.84 | DHODH (0.56) | HIF1ASERPINE1DHODHMEN1KMT2A | |
| SCHEMBL22453034 | 0.84 | HIF1A (0.61) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL22453009 | 0.83 | DHODH (0.54) | HIF1ASERPINE1DHODHMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |