Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.61 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.51 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MDH1 | P40925 | 1/20 | 0.48 |
| ▸ | MDH2 | P40926 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452679 | 0.97 | HIF1A (0.62) | HIF1AEPAS1EPHX2PGRNPC1 | |
| SCHEMBL22452806 | 0.95 | HIF1A (0.59) | HIF1AEPAS1EPHX2PGRNPC1 | |
| SCHEMBL22452489 | 0.92 | HIF1A (0.62) | HIF1AEPAS1EPHX2PGRNPC1 | |
| SCHEMBL22453542 | 0.88 | HIF1A (0.64) | HIF1AEPAS1EPHX2NPC1MDH1 | |
| SCHEMBL22453544 | 0.88 | EPHX2 (0.54) | HIF1AEPAS1EPHX2NPC1HPSE | |
| SCHEMBL22452690 | 0.87 | SIRT2 (0.57) | HIF1AEPAS1EPHX2PGRNPC1 | |
| SCHEMBL22452754 | 0.85 | SERPINE1 (0.58) | HIF1AEPAS1EPHX2PGRSERPINE1 | |
| SCHEMBL22453225 | 0.84 | HIF1A (0.66) | HIF1AEPAS1EPHX2MEN1KMT2A | |
| SCHEMBL22452701 | 0.84 | HIF1A (0.49) | HIF1AEPAS1PGRNPC1SERPINE1 | |
| SCHEMBL22453158 | 0.82 | NPC1 (0.56) | HIF1AEPAS1EPHX2PGRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |