Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453009 | 0.98 | DHODH (0.54) | DHODHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL22452682 | 0.97 | DHODH (0.56) | DHODHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL22453633 | 0.93 | DHODH (0.51) | DHODHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL22453108 | 0.88 | CNR2 (0.59) | DHODHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL22453002 | 0.88 | DHODH (0.50) | DHODHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL22452895 | 0.86 | CNR2 (0.57) | DHODHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL22453548 | 0.85 | CNR2 (0.56) | DHODHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL22452701 | 0.85 | HIF1A (0.49) | DHODHKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL22453640 | 0.84 | DHODH (0.57) | DHODHKMT2AMEN1LMNAHIF1A | |
| SCHEMBL22453641 | 0.83 | DHODH (0.55) | DHODHKMT2AMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |