Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 12/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 12/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452661 | 0.97 | MEN1 (0.57) | MEN1LMNAKMT2APOLBMAPT | |
| SCHEMBL22452600 | 0.92 | MTNR1A (0.45) | MEN1LMNAKMT2APOLBMAPT | |
| SCHEMBL22452455 | 0.91 | MEN1 (0.55) | MEN1LMNAKMT2APOLBMAPT | |
| SCHEMBL22452734 | 0.89 | MEN1 (0.53) | MEN1LMNAKMT2APOLBMAPT | |
| SCHEMBL22452989 | 0.89 | KDM4C (0.44) | MEN1LMNAKMT2APOLBMAPT | |
| SCHEMBL22453047 | 0.89 | MEN1 (0.53) | MEN1LMNAKMT2APOLBMAPT | |
| SCHEMBL22452453 | 0.89 | MEN1 (0.48) | MEN1LMNAKMT2APOLBMAPT | |
| SCHEMBL22453437 | 0.89 | MTNR1A (0.46) | MEN1LMNAKMT2APOLBMAPT | |
| SCHEMBL22452473 | 0.88 | MEN1 (0.52) | MEN1LMNAKMT2APOLBMAPT | |
| SCHEMBL22452555 | 0.88 | KDM4C (0.44) | MEN1LMNAKMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |