Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452600 | 0.97 | MTNR1A (0.45) | MTNR1AMTNR1BMEN1LMNAKMT2A | |
| SCHEMBL22453405 | 0.92 | MTNR1A (0.44) | MTNR1AMTNR1BMEN1LMNAKMT2A | |
| SCHEMBL22452661 | 0.92 | MEN1 (0.57) | MTNR1AMTNR1BMEN1LMNAKMT2A | |
| SCHEMBL22453183 | 0.90 | MTNR1A (0.43) | MTNR1AMTNR1BMEN1LMNAKMT2A | |
| SCHEMBL22452954 | 0.90 | MTNR1A (0.43) | MTNR1AMTNR1BMEN1LMNAKMT2A | |
| SCHEMBL22452918 | 0.89 | MTNR1A (0.42) | MTNR1AMTNR1BMEN1LMNAKMT2A | |
| SCHEMBL22453589 | 0.89 | MTNR1A (0.42) | MTNR1AMTNR1BMEN1LMNAKMT2A | |
| SCHEMBL22452722 | 0.89 | MEN1 (0.56) | MTNR1AMTNR1BMEN1LMNAKMT2A | |
| SCHEMBL22453438 | 0.86 | MTNR1A (0.41) | MTNR1AMTNR1BMAPTPOLBKDM4E | |
| SCHEMBL22453177 | 0.86 | MAPT (0.39) | MTNR1AMTNR1BMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |