Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 15/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452957 | 0.93 | DHODH (0.42) | DHODHMEN1LMNAKMT2APOLB | |
| SCHEMBL22452865 | 0.89 | DHODH (0.49) | DHODHMEN1LMNAKMT2APOLB | |
| SCHEMBL22452722 | 0.89 | MEN1 (0.56) | DHODHMEN1LMNAKMT2APOLB | |
| SCHEMBL22452453 | 0.86 | MEN1 (0.48) | DHODHMEN1LMNAKMT2APOLB | |
| SCHEMBL22452661 | 0.86 | MEN1 (0.57) | DHODHMEN1LMNAKMT2APOLB | |
| SCHEMBL22452732 | 0.83 | DHODH (0.46) | DHODHMEN1LMNAKMT2APOLB | |
| SCHEMBL22453021 | 0.82 | DHODH (0.44) | DHODHMEN1LMNAKMT2APOLB | |
| SCHEMBL22452989 | 0.82 | KDM4C (0.44) | DHODHMEN1LMNAKMT2APOLB | |
| SCHEMBL22452910 | 0.82 | DHODH (0.41) | DHODHMEN1LMNAKMT2APOLB | |
| SCHEMBL22452455 | 0.82 | MEN1 (0.55) | DHODHMEN1LMNAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |