Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453177 | 0.95 | MAPT (0.39) | DHODHMCHR1PROKR1MTNR1AMTNR1B | |
| SCHEMBL22452865 | 0.93 | DHODH (0.49) | DHODHMAPTMEN1LMNAPOLB | |
| SCHEMBL22452957 | 0.89 | DHODH (0.42) | DHODHMCHR1PROKR1MTNR1AMTNR1B | |
| SCHEMBL22452600 | 0.89 | MTNR1A (0.45) | MCHR1MTNR1AMTNR1BMAPTMEN1 | |
| SCHEMBL22452453 | 0.88 | MEN1 (0.48) | DHODHMAPTMEN1LMNAPOLB | |
| SCHEMBL22452914 | 0.87 | AXL (0.39) | DHODHMCHR1PROKR1MAPTMEN1 | |
| SCHEMBL22453437 | 0.86 | MTNR1A (0.46) | DHODHMTNR1AMTNR1BMAPTMEN1 | |
| SCHEMBL22452913 | 0.83 | LIPE (0.44) | DHODHMAPTMEN1LMNAPOLB | |
| SCHEMBL22452735 | 0.82 | DHODH (0.50) | DHODHMAPTMEN1LMNAPOLB | |
| SCHEMBL22452960 | 0.82 | DHODH (0.45) | DHODHMAPTMEN1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |