Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.38 |
| ▸ | LTC4S | Q16873 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453012 | 0.94 | LTC4S (0.39) | SERPINE1LTC4SHIF1AEPAS1KMT2A | |
| SCHEMBL22453245 | 0.87 | LTC4S (0.41) | SERPINE1LTC4SHIF1AEPAS1KMT2A | |
| SCHEMBL22452747 | 0.85 | SERPINE1 (0.41) | SERPINE1LTC4SHIF1AEPAS1KMT2A | |
| SCHEMBL22453211 | 0.81 | DHODH (0.47) | SERPINE1LTC4SHIF1AKMT2ASMN1; SMN2 | |
| SCHEMBL22452697 | 0.81 | SERPINE1 (0.41) | SERPINE1LTC4SHIF1AEPAS1KMT2A | |
| SCHEMBL22453242 | 0.81 | HIF1A (0.43) | SERPINE1LTC4SHIF1AEPAS1KMT2A | |
| SCHEMBL22453036 | 0.81 | HIF1A (0.36) | SERPINE1LTC4SHIF1AEPAS1KMT2A | |
| SCHEMBL22452973 | 0.81 | CNR2 (0.40) | HIF1AEPAS1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL22453014 | 0.78 | HIF1A (0.37) | SERPINE1LTC4SHIF1AEPAS1KMT2A | |
| SCHEMBL22452487 | 0.77 | HIF1A (0.47) | SERPINE1HIF1AEPAS1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |