Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.51 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 12/20 | 0.48 |
| ▸ | PPARA | Q07869 | 9/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452752 | 0.89 | SIRT2 (0.59) | HIF1AEPAS1MT-CO2PPARGPPARA | |
| SCHEMBL22452527 | 0.86 | SERPINE1 (0.57) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL22453497 | 0.86 | SERPINE1 (0.57) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL31555348 | 0.85 | HIF1A (0.60) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL22452498 | 0.85 | HIF1A (0.60) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL22452488 | 0.83 | SERPINE1 (0.64) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL22453247 | 0.81 | EPHX2 (0.65) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL22453340 | 0.80 | HIF1A (0.56) | HIF1AEPAS1MEN1KMT2ASIRT2 | |
| SCHEMBL22453626 | 0.80 | SERPINE1 (0.65) | HIF1AEPAS1SERPINE1MEN1KMT2A | |
| SCHEMBL22452502 | 0.80 | HIF1A (0.54) | HIF1AEPAS1SERPINE1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |