Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453160 | 0.85 | LMNA (0.56) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL22453165 | 0.84 | ALDH1A1 (0.79) | ALDH1A1LMNAMAPTCYP1A2CYP3A4 | |
| SCHEMBL21039142 | 0.77 | ALDH1A1 (0.60) | ALDH1A1LMNAMAPTCYP3A4L3MBTL1 | |
| SCHEMBL31168054 | 0.77 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPTHTTMEN1 | |
| SCHEMBL22452681 | 0.77 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPTHTTMEN1 | |
| SCHEMBL22452793 | 0.76 | MEN1 (0.46) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL23194883 | 0.76 | MAPT (0.37) | ALDH1A1LMNAMAPTCYP3A4ALOX12 | |
| SCHEMBL22815320 | 0.76 | EPHX2 (0.57) | ALDH1A1LMNAMAPTALOX12L3MBTL1 | |
| SCHEMBL27847928 | 0.75 | MEN1 (0.59) | ALDH1A1LMNAMAPTHTTL3MBTL1 | |
| SCHEMBL22453380 | 0.74 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |