Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453118 | 0.86 | CA12 (0.42) | EPHX2MEN1KMT2APOLBGAA | |
| SCHEMBL22453641 | 0.85 | DHODH (0.55) | MEN1KMT2ANPC1SERPINE1LMNA | |
| SCHEMBL22453269 | 0.83 | SERPINE1 (0.42) | EPHX2MEN1KMT2APOLBNPC1 | |
| SCHEMBL22453117 | 0.82 | CNR2 (0.53) | MEN1KMT2AGAANPC1SMN1; SMN2 | |
| SCHEMBL22452529 | 0.81 | DHODH (0.41) | MEN1KMT2ANPC1SERPINE1P2RX7 | |
| SCHEMBL22453106 | 0.81 | EPHX2 (0.39) | EPHX2MEN1KMT2APOLBGAA | |
| SCHEMBL22452941 | 0.81 | HIF1A (0.40) | EPHX2NPC1SERPINE1P2RX4P2RX7 | |
| SCHEMBL22453267 | 0.80 | SERPINE1 (0.42) | EPHX2MEN1KMT2APOLBGAA | |
| SCHEMBL22453640 | 0.79 | DHODH (0.57) | MEN1KMT2AGAANPC1SERPINE1 | |
| SCHEMBL22452681 | 0.78 | ALDH1A1 (0.57) | EPHX2MEN1KMT2APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |