Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453348 | 0.89 | KMT2A (0.42) | CNR2CNR1BRAFSMN1; SMN2ABL1 | |
| SCHEMBL22452937 | 0.83 | DHODH (0.40) | P2RX3MAPTDHODHTP53CYP1A2 | |
| SCHEMBL22453715 | 0.82 | GAA (0.38) | MAPTDHODHTP53CYP1A2 | |
| SCHEMBL22453088 | 0.81 | DHODH (0.42) | SMN1; SMN2PTGESALOX5DHODHEGLN1 | |
| SCHEMBL22452817 | 0.80 | KDM1A (0.42) | SMN1; SMN2MAPTPTGESALOX5DHODH | |
| SCHEMBL22452643 | 0.76 | CNR2 (0.46) | CNR2BRAFMAPTNPC1CYP1A2 | |
| SCHEMBL22452645 | 0.75 | KDM1A (0.37) | CNR2BRAFALOX5DHODH | |
| SCHEMBL22453372 | 0.74 | GAA (0.49) | SMN1; SMN2MAPTDHODHSERPINE1 | |
| SCHEMBL22452646 | 0.73 | SERPINE1 (0.50) | SMN1; SMN2MAPTPTGESGRM4SERPINE1 | |
| SCHEMBL22453062 | 0.73 | DHODH (0.52) | SMN1; SMN2MAPTDHODHSERPINE1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |