Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453371 | 0.82 | ALDH1A1 (0.40) | GAATDP1HTTALDH1A1ALOX15 | |
| SCHEMBL22453375 | 0.78 | KDM1A (0.40) | GAATDP1HTTALDH1A1ALOX15 | |
| SCHEMBL22453374 | 0.77 | SMN1; SMN2 (0.66) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL22453348 | 0.76 | KMT2A (0.42) | TDP1HTTALDH1A1MEN1KMT2A | |
| SCHEMBL22453062 | 0.75 | DHODH (0.52) | TDP1HTTALDH1A1LMNAMAPT | |
| SCHEMBL6100303 | 0.75 | KMO (0.53) | ALDH1A1MAPTKDM4EGFERTDO2 | |
| SCHEMBL1176491 | 0.75 | KMO (0.53) | ALDH1A1MAPTKDM4EGFERTDO2 | |
| SCHEMBL21332384 | 0.73 | KMO (0.51) | GAATDP1HTTALDH1A1LMNA | |
| SCHEMBL16334825 | 0.73 | HDAC4 (0.52) | GAATDP1ALDH1A1LMNAMAPT | |
| SCHEMBL2652971 | 0.72 | TDO2 (0.40) | GAAHTTALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |