Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 6/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452817 | 0.90 | KDM1A (0.42) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL22453088 | 0.89 | DHODH (0.42) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL22452933 | 0.89 | P2RX3 (0.39) | SMN1; SMN2DHODHSERPINE1EGLN1PTGES | |
| SCHEMBL22453062 | 0.79 | DHODH (0.52) | KMT2AHTTSMN1; SMN2HIF1ATDP1 | |
| SCHEMBL22452937 | 0.78 | DHODH (0.40) | KMT2ADHODHMEN1ALDH1A1 | |
| SCHEMBL22453086 | 0.76 | SERPINE1 (0.35) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL22453372 | 0.76 | GAA (0.49) | KMT2AKDM4EHTTSMN1; SMN2TDP1 | |
| SCHEMBL22452985 | 0.76 | SERPINE1 (0.43) | KMT2AKDM4ESMN1; SMN2HIF1ASERPINE1 | |
| SCHEMBL22453293 | 0.76 | PTGES (0.43) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL22453059 | 0.75 | AKR1C3 (0.57) | KMT2ADHODHSERPINE1KMOMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |