Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MDH1 | P40925 | 2/20 | 0.35 |
| ▸ | MDH2 | P40926 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452560 | 0.90 | SERPINE1 (0.40) | HIF1ANPC1SERPINE1ALDH1A1 | |
| SCHEMBL22453556 | 0.83 | HIF1A (0.56) | HIF1ANPC1EPAS1MAPTNPSR1 | |
| SCHEMBL22452942 | 0.81 | HIF1A (0.41) | HIF1ANPC1EPAS1MAPTNPSR1 | |
| SCHEMBL22453555 | 0.81 | HIF1A (0.44) | HIF1ANPC1EPAS1MAPTNPSR1 | |
| SCHEMBL22453720 | 0.81 | KMT2A (0.40) | HIF1ANPC1EPAS1MAPTNPSR1 | |
| SCHEMBL22453416 | 0.79 | HIF1A (0.42) | HIF1ANPC1EPAS1MAPTSERPINE1 | |
| SCHEMBL22453312 | 0.79 | SERPINE1 (0.43) | HIF1ANPC1EPAS1SERPINE1ALDH1A1 | |
| SCHEMBL22453525 | 0.79 | MAPT (0.50) | HIF1ANPC1EPAS1MAPTMDH1 | |
| SCHEMBL22453408 | 0.78 | HIF1A (0.40) | HIF1ANPC1EPAS1MAPTNPSR1 | |
| SCHEMBL22452750 | 0.78 | NPC1 (0.38) | HIF1ANPC1EPAS1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |