Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.54 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453450 | 0.93 | EPHX2 (0.56) | EPHX2HPSEHIF1AEPAS1MEN1 | |
| SCHEMBL22453343 | 0.88 | SIRT2 (0.54) | EPHX2MEN1KMT2AMAPK14PKM | |
| SCHEMBL22453034 | 0.88 | HIF1A (0.61) | EPHX2HPSEHIF1AEPAS1MEN1 | |
| SCHEMBL22452679 | 0.84 | HIF1A (0.62) | EPHX2HPSEHIF1AEPAS1MEN1 | |
| SCHEMBL22452806 | 0.83 | HIF1A (0.59) | EPHX2HPSEHIF1AEPAS1MEN1 | |
| SCHEMBL22453777 | 0.81 | EPHX2 (0.58) | EPHX2HIF1AEPAS1MEN1KMT2A | |
| SCHEMBL22452489 | 0.80 | HIF1A (0.62) | EPHX2HPSEHIF1AEPAS1MEN1 | |
| SCHEMBL22453268 | 0.80 | EPHX2 (0.55) | EPHX2MEN1KMT2ANPC1 | |
| SCHEMBL22453542 | 0.76 | HIF1A (0.64) | EPHX2HIF1AEPAS1NPC1RAB9A | |
| SCHEMBL24292257 | 0.75 | ALDH1A1 (0.43) | EPHX2MEN1KMT2APKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |