Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 5/20 | 0.48 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452646 | 0.90 | SERPINE1 (0.50) | SERPINE1SIRT2MEN1KMT2APKM | |
| SCHEMBL22453382 | 0.88 | SERPINE1 (0.58) | SERPINE1MEN1KMT2ADHODHALDH1A1 | |
| SCHEMBL22453347 | 0.88 | SERPINE1 (0.58) | SERPINE1MEN1KMT2ADHODHALDH1A1 | |
| SCHEMBL22453286 | 0.87 | SERPINE1 (0.56) | SERPINE1MEN1KMT2APKMDHODH | |
| SCHEMBL22453284 | 0.87 | SIRT2 (0.60) | SERPINE1SIRT2MEN1KMT2APKM | |
| SCHEMBL22452796 | 0.83 | SERPINE1 (0.48) | SERPINE1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL22452642 | 0.81 | SERPINE1 (0.47) | SERPINE1MEN1KMT2ADHODHNPC1 | |
| SCHEMBL22452640 | 0.79 | SERPINE1 (0.49) | SERPINE1MEN1KMT2APKMALDH1A1 | |
| SCHEMBL22453374 | 0.79 | SMN1; SMN2 (0.66) | SERPINE1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL22453062 | 0.77 | DHODH (0.52) | SERPINE1MEN1KMT2APKMDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |