Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | FABP3 | P05413 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452796 | 0.93 | SERPINE1 (0.48) | SERPINE1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL22453347 | 0.91 | SERPINE1 (0.58) | SERPINE1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL22453063 | 0.88 | SERPINE1 (0.60) | SERPINE1MEN1KMT2APOLBDHODH | |
| SCHEMBL22452642 | 0.86 | SERPINE1 (0.47) | SERPINE1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL22452646 | 0.86 | SERPINE1 (0.50) | SERPINE1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL22453286 | 0.81 | SERPINE1 (0.56) | SERPINE1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL22452475 | 0.81 | MEN1 (0.58) | SERPINE1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL22452640 | 0.79 | SERPINE1 (0.49) | SERPINE1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL22452719 | 0.77 | DHODH (0.51) | MEN1KMT2ALMNASMN1; SMN2HPGD | |
| SCHEMBL22453374 | 0.76 | SMN1; SMN2 (0.66) | SERPINE1MEN1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |