Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14113410 | 0.84 | SERPINE1 (0.57) | MEN1KMT2AMAPTSERPINE1NPC1 | |
| SCHEMBL22453063 | 0.79 | SERPINE1 (0.60) | MEN1KMT2ASERPINE1KMONPC1 | |
| SCHEMBL22453372 | 0.77 | GAA (0.49) | SMN1; SMN2MEN1KMT2AMAPTSERPINE1 | |
| SCHEMBL22452646 | 0.77 | SERPINE1 (0.50) | SMN1; SMN2NPSR1HSD17B10MEN1KMT2A | |
| SCHEMBL3824109 | 0.77 | CA1 (0.48) | SMN1; SMN2NPSR1HSD17B10MEN1KMT2A | |
| SCHEMBL3769385 | 0.76 | NPSR1 (0.80) | SMN1; SMN2NPSR1HSD17B10MEN1KMT2A | |
| SCHEMBL22453286 | 0.76 | SERPINE1 (0.56) | SMN1; SMN2MEN1KMT2AMAPTSERPINE1 | |
| SCHEMBL864819 | 0.76 | MEN1 (1.00) | SMN1; SMN2NPSR1HSD17B10MEN1KMT2A | |
| SCHEMBL18147885 | 0.76 | SMN1; SMN2 (0.78) | SMN1; SMN2NPSR1HSD17B10MEN1KMT2A | |
| SCHEMBL22453347 | 0.76 | SERPINE1 (0.58) | SMN1; SMN2MEN1KMT2ASERPINE1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |