Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452725 | 0.96 | MEN1 (0.46) | MEN1KMT2ALMNASLC25A1ALDH1A1 | |
| SCHEMBL22453775 | 0.90 | LMNA (0.49) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL22452486 | 0.89 | HIF1A (0.50) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL22453774 | 0.86 | LMNA (0.47) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL22453073 | 0.86 | DHODH (0.47) | MEN1KMT2ALMNAALDH1A1SERPINE1 | |
| SCHEMBL22453449 | 0.85 | HIF1A (0.51) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL22452710 | 0.84 | MEN1 (0.44) | MEN1KMT2ALMNASLC25A1ALDH1A1 | |
| SCHEMBL22452715 | 0.83 | SERPINE1 (0.64) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL22453520 | 0.82 | SERPINE1 (0.51) | MEN1KMT2ALMNAALDH1A1HIF1A | |
| SCHEMBL31555349 | 0.82 | SERPINE1 (0.51) | MEN1KMT2ALMNAALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |