Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453281 | 0.89 | HIF1A (0.44) | CNR2L3MBTL1EPHX2LMNAMAPT | |
| SCHEMBL22452757 | 0.73 | EPHX2 (0.49) | EPHX2LMNAMAPTHIF1APGR | |
| SCHEMBL24292257 | 0.70 | ALDH1A1 (0.43) | L3MBTL1EPHX2LMNAMAPTALDH1A1 | |
| SCHEMBL10749534 | 0.68 | KMT2A (0.45) | LMNAMAPTALDH1A1THRB | |
| SCHEMBL10749539 | 0.68 | KMT2A (0.45) | LMNAMAPTALDH1A1THRB | |
| SCHEMBL10783189 | 0.67 | CA12 (0.59) | L3MBTL1LMNAMAPTMDM2ALDH1A1 | |
| SCHEMBL4796094 | 0.67 | MAPT (0.51) | LMNAMAPTMDM2ALDH1A1THRB | |
| SCHEMBL22453268 | 0.67 | EPHX2 (0.55) | EPHX2THRBRECQL | |
| SCHEMBL8740665 | 0.67 | MAPT (0.55) | LMNAMAPTMDM2ALDH1A1THRB | |
| SCHEMBL22815550 | 0.67 | EPHX2 (0.40) | L3MBTL1EPHX2LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |