Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453099 | 0.89 | CNR2 (0.41) | HIF1AEPHX2CNR2L3MBTL1LMNA | |
| SCHEMBL22452757 | 0.84 | EPHX2 (0.49) | HIF1AEPHX2NPC1EPAS1LMNA | |
| SCHEMBL22453750 | 0.77 | CYP4F2 (0.44) | HIF1AEPHX2NPC1CNR2EPAS1 | |
| SCHEMBL22453741 | 0.77 | EPHX2 (0.49) | HIF1AEPHX2NPC1EPAS1LMNA | |
| SCHEMBL22452503 | 0.73 | MAPT (0.58) | HIF1AEPHX2NPC1CNR2EPAS1 | |
| SCHEMBL22453102 | 0.73 | EPHX2 (0.49) | HIF1AEPHX2NPC1EPAS1LMNA | |
| SCHEMBL22453029 | 0.72 | EPHX2 (0.48) | HIF1AEPHX2NPC1CNR2EPAS1 | |
| SCHEMBL22452479 | 0.72 | EPHX2 (0.50) | HIF1AEPHX2NPC1CNR2EPAS1 | |
| SCHEMBL22452498 | 0.71 | HIF1A (0.60) | HIF1AEPHX2NPC1EPAS1LMNA | |
| SCHEMBL31555348 | 0.71 | HIF1A (0.60) | HIF1AEPHX2NPC1EPAS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |