Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452656 | 0.92 | EPHX2 (0.47) | HIF1ANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL22453279 | 0.90 | NPC1 (0.43) | HIF1ANPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL22452576 | 0.88 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2GAAHPGD | |
| SCHEMBL22453425 | 0.86 | HIF1A (0.43) | HIF1ACYP2C9NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22452982 | 0.86 | CYP2C9 (0.48) | HIF1ACYP2C9NPC1SMN1; SMN2PGR | |
| SCHEMBL22452808 | 0.86 | CYP2C9 (0.48) | HIF1ACYP2C9NPC1SMN1; SMN2PGR | |
| SCHEMBL22453173 | 0.84 | HSP90AA1 (0.45) | HIF1ACYP2C9NPC1SMN1; SMN2RECQL | |
| SCHEMBL22453416 | 0.82 | HIF1A (0.42) | HIF1ANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL22453689 | 0.81 | CYP2C9 (0.44) | HIF1ACYP2C9NPC1SMN1; SMN2PGR | |
| SCHEMBL22452559 | 0.81 | CNR2 (0.43) | NPC1RAB9ASMN1; SMN2HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |