Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453116 | 0.92 | HIF1A (0.47) | HIF1ANPC1CYP1A2RAB9AMAPT | |
| SCHEMBL22453425 | 0.89 | HIF1A (0.43) | HIF1ANPC1CYP1A2RAB9AMAPT | |
| SCHEMBL22453173 | 0.86 | HSP90AA1 (0.45) | EPHX2HIF1ANPC1CYP1A2MAPT | |
| SCHEMBL22452799 | 0.85 | EPHX2 (0.53) | EPHX2HIF1ANPC1MAPTEPAS1 | |
| SCHEMBL22453416 | 0.84 | HIF1A (0.42) | HIF1ANPC1CYP1A2RAB9AMAPT | |
| SCHEMBL22453279 | 0.82 | NPC1 (0.43) | EPHX2HIF1ANPC1CYP1A2RAB9A | |
| SCHEMBL22453333 | 0.82 | CYP1A2 (0.43) | EPHX2HIF1ANPC1CYP1A2RAB9A | |
| SCHEMBL22453334 | 0.82 | HIF1A (0.43) | HIF1ACYP1A2MAPTEPAS1 | |
| SCHEMBL22453603 | 0.80 | HIF1A (0.43) | HIF1ANPC1CYP1A2RAB9AMAPT | |
| SCHEMBL22452576 | 0.79 | NPC1 (0.42) | EPHX2NPC1CYP1A2RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |