Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452656 | 0.89 | EPHX2 (0.47) | HIF1ACYP1A2NPC1MAPTLMNA | |
| SCHEMBL22453446 | 0.86 | NPC1 (0.44) | HIF1ANPC1MAPTNPSR1LMNA | |
| SCHEMBL22453116 | 0.86 | HIF1A (0.47) | HIF1ACYP1A2NPC1MAPTNPSR1 | |
| SCHEMBL22453173 | 0.85 | HSP90AA1 (0.45) | HIF1ACYP1A2NPC1MAPTNPSR1 | |
| SCHEMBL22453416 | 0.83 | HIF1A (0.42) | HIF1ACYP1A2NPC1MAPTSMN1; SMN2 | |
| SCHEMBL22453333 | 0.80 | CYP1A2 (0.43) | HIF1ACYP1A2NPC1MAPTNPSR1 | |
| SCHEMBL22453334 | 0.80 | HIF1A (0.43) | HIF1ACYP1A2MAPTSLC2A1EPAS1 | |
| SCHEMBL22453203 | 0.80 | CNR2 (0.54) | HIF1ANPC1MAPTNPSR1LMNA | |
| SCHEMBL22453580 | 0.79 | DHODH (0.50) | CYP1A2NPC1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL22452481 | 0.77 | PGR (0.48) | HIF1ANPC1MAPTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |