Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452655 | 0.91 | CNR2 (0.46) | SERPINE1NPC1CYP2C9PGRHIF1A | |
| SCHEMBL22453241 | 0.89 | NPC1 (0.44) | SERPINE1NPC1PGRHIF1AEPAS1 | |
| SCHEMBL22453242 | 0.88 | HIF1A (0.43) | SERPINE1NPC1CYP2C9PGRHIF1A | |
| SCHEMBL22453243 | 0.85 | SERPINE1 (0.50) | SERPINE1NPC1CYP2C9PGRHIF1A | |
| SCHEMBL22453245 | 0.84 | LTC4S (0.41) | SERPINE1NPC1CYP2C9PGRHIF1A | |
| SCHEMBL22452487 | 0.84 | HIF1A (0.47) | SERPINE1NPC1PGRHIF1AEPAS1 | |
| SCHEMBL22453240 | 0.82 | DHODH (0.54) | SERPINE1NPC1CYP2C9PGRHIF1A | |
| SCHEMBL22452700 | 0.80 | GAA (0.38) | CYP2C9PGRHIF1AEPAS1MAPT | |
| SCHEMBL22453152 | 0.80 | CNR2 (0.47) | NPC1PGRHIF1AEPAS1MAPT | |
| SCHEMBL22452627 | 0.79 | CNR2 (0.51) | NPC1PGRHIF1AEPAS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |