Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.41 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453292 | 0.90 | SERPINE1 (0.58) | SERPINE1PPARGPPARANR1H4DHODH | |
| SCHEMBL22453805 | 0.87 | SERPINE1 (0.51) | SERPINE1PPARGPPARANR1H4DHODH | |
| SCHEMBL22453784 | 0.86 | SERPINE1 (0.56) | SERPINE1PPARGPPARANR1H4DHODH | |
| SCHEMBL22452711 | 0.82 | DHODH (0.48) | SERPINE1DHODHHIF1AEPAS1MEN1 | |
| SCHEMBL22452488 | 0.79 | SERPINE1 (0.64) | SERPINE1DHODHHIF1AEPAS1MEN1 | |
| SCHEMBL22453343 | 0.79 | SIRT2 (0.54) | SERPINE1ALDH1A1MEN1KMT2APKM | |
| SCHEMBL22452715 | 0.79 | SERPINE1 (0.64) | SERPINE1PPARGPPARANR1H4DHODH | |
| SCHEMBL22453497 | 0.76 | SERPINE1 (0.57) | SERPINE1DHODHHIF1AEPAS1MEN1 | |
| SCHEMBL22452527 | 0.76 | SERPINE1 (0.57) | SERPINE1DHODHHIF1AEPAS1MEN1 | |
| SCHEMBL22453626 | 0.76 | SERPINE1 (0.65) | SERPINE1DHODHHIF1AEPAS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |