Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452817 | 0.88 | KDM1A (0.42) | PTGESALOX5AURKAMAPTPOLB | |
| SCHEMBL22453578 | 0.86 | MAPT (0.42) | PTGESALOX5AURKAMAPTPOLB | |
| SCHEMBL22452818 | 0.81 | AKR1C3 (0.67) | AURKAPOLBAKR1C3AKR1C2KDM1A | |
| SCHEMBL22452823 | 0.80 | RAF1 (0.41) | PTGESALOX5MAPTPOLBLMNA | |
| SCHEMBL18286208 | 0.76 | AURKA (0.60) | AURKAMAPTLMNAAKR1C3AKR1C2 | |
| SCHEMBL22453713 | 0.76 | RAF1 (0.40) | MAPTKDM1AKMT2AMEN1ALDH1A1 | |
| SCHEMBL22453348 | 0.76 | KMT2A (0.42) | PTGESALOX5POLBKMT2AKDM4E | |
| SCHEMBL22453714 | 0.74 | AKR1C3 (0.51) | MAPTPOLBAKR1C3AKR1C2KMT2A | |
| SCHEMBL22452932 | 0.72 | KDM1A (0.40) | MAPTLMNAKDM1AKMT2AHTT | |
| SCHEMBL22453260 | 0.70 | LTC4S (0.44) | AURKAMAPTLMNAAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |