Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3143329 | 0.86 | ALDH1A1 (0.52) | LTA4HALDH1A1KDM4ETSHRHDAC8 | |
| SCHEMBL19465330 | 0.86 | LTA4H (0.63) | LTA4HALDH1A1SMN1; SMN2KDM4EADRA1D | |
| SCHEMBL952721 | 0.86 | LTA4H (0.63) | LTA4HALDH1A1SMN1; SMN2KDM4EADRA1D | |
| SCHEMBL952722 | 0.86 | LTA4H (0.63) | LTA4HALDH1A1SMN1; SMN2KDM4EADRA1D | |
| SCHEMBL3573555 | 0.86 | ALDH1A1 (0.51) | LTA4HALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL27358578 | 0.85 | ALDH1A1 (0.52) | LTA4HALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL24434971 | 0.84 | ALDH1A1 (0.51) | LTA4HALDH1A1KDM4EGAAL3MBTL1 | |
| SCHEMBL200204 | 0.83 | CD274 (0.51) | ALDH1A1SMN1; SMN2KDM4ETSHRMMP2 | |
| SCHEMBL200203 | 0.83 | CD274 (0.51) | ALDH1A1SMN1; SMN2KDM4ETSHRMMP2 | |
| SCHEMBL6540812 | 0.82 | MEN1 (0.60) | LTA4HALDH1A1SMN1; SMN2KDM4EFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |