Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453489 | 0.96 | KMT2A (0.42) | KMT2ASLC7A5GAANPSR1ABCB1 | |
| SCHEMBL22452884 | 0.86 | KMT2A (0.48) | KMT2AGAANPSR1SLC6A3ALDH1A1 | |
| SCHEMBL4956421 | 0.78 | KMT2A (0.59) | KMT2AGAANPSR1SLC6A3ALDH1A1 | |
| SCHEMBL11351276 | 0.78 | RORC (0.51) | KMT2AALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL558157 | 0.75 | TSHR (0.53) | KMT2ASLC7A5ALDH1A1MAPTTSHR | |
| SCHEMBL4444645 | 0.75 | KMT2A (0.67) | KMT2AGAANPSR1SLC6A3ALDH1A1 | |
| SCHEMBL27684757 | 0.74 | SLC7A5 (0.50) | KMT2ASLC7A5ABCB1ABCG2ALDH1A1 | |
| SCHEMBL5608478 | 0.74 | TSHR (0.58) | KMT2ASLC7A5ALDH1A1MAPTTSHR | |
| SCHEMBL2685272 | 0.74 | BRD4 (0.48) | SLC7A5ALDH1A1MAPTTSHRCASR | |
| SCHEMBL27969442 | 0.73 | KMT2A (0.54) | KMT2AGAANPSR1SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |