Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.37 |
| ▸ | PPARA | Q07869 | 4/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453733 | 0.80 | LMNA (0.39) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21572358 | 0.74 | KMT2A (0.48) | SLC6A2SLC6A4SLC6A3KDM4EKMT2A | |
| SCHEMBL22452618 | 0.74 | LMNA (0.38) | PPARGPPARABACE1SLC6A2SLC6A4 | |
| SCHEMBL22452911 | 0.73 | MAPK10 (0.44) | PPARGPPARAKDM4EPOLBGLA | |
| SCHEMBL22453697 | 0.72 | PDE7A (0.48) | PPARGPPARABACE1SLC6A2SLC6A4 | |
| SCHEMBL4060269 | 0.72 | CYP3A4 (0.55) | SLC6A2SLC6A4SLC6A3KMT2ASMN1; SMN2 | |
| SCHEMBL3786337 | 0.69 | SLC6A2 (0.49) | BACE1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL790114 | 0.69 | BACE1 (0.47) | BACE1TDP1 | |
| SCHEMBL27544170 | 0.67 | PPARG (0.51) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3781164 | 0.67 | SLC6A2 (0.50) | BACE1SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |