Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452717 | 0.82 | SERPINE1 (0.48) | SERPINE1MEN1KMT2AHTTRAB9A | |
| SCHEMBL22452715 | 0.82 | SERPINE1 (0.64) | SERPINE1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL22452789 | 0.79 | SERPINE1 (0.61) | SERPINE1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL22453243 | 0.77 | SERPINE1 (0.50) | SERPINE1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL22452704 | 0.75 | SERPINE1 (0.61) | SERPINE1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL22453520 | 0.74 | SERPINE1 (0.51) | SERPINE1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL31555349 | 0.74 | SERPINE1 (0.51) | SERPINE1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL22452527 | 0.74 | SERPINE1 (0.57) | SERPINE1MEN1KMT2ANPC1PGR | |
| SCHEMBL22453497 | 0.74 | SERPINE1 (0.57) | SERPINE1MEN1KMT2ANPC1PGR | |
| SCHEMBL22452486 | 0.74 | HIF1A (0.50) | SERPINE1MEN1KMT2AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |