Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453243 | 0.89 | SERPINE1 (0.50) | SERPINE1PGRNPC1HIF1AEPAS1 | |
| SCHEMBL22453627 | 0.82 | SERPINE1 (0.46) | SERPINE1PGRNPC1HIF1AEPAS1 | |
| SCHEMBL22452514 | 0.82 | NPC1 (0.47) | SERPINE1PGRNPC1HIF1AEPAS1 | |
| SCHEMBL22453768 | 0.81 | USP2 (0.42) | NPC1USP2HIF1AEPAS1EPHX2 | |
| SCHEMBL22452516 | 0.80 | HIF1A (0.47) | SERPINE1PGRNPC1HIF1AEPAS1 | |
| SCHEMBL22452699 | 0.80 | FAAH (0.53) | USP2EPHX2MAPTHTTLMNA | |
| SCHEMBL22452690 | 0.79 | SIRT2 (0.57) | SERPINE1PGRNPC1HIF1AEPAS1 | |
| SCHEMBL22452984 | 0.78 | PGR (0.55) | SERPINE1PGRNPC1HIF1AEPAS1 | |
| SCHEMBL22453453 | 0.76 | PGR (0.47) | SERPINE1PGRNPC1HIF1AEPAS1 | |
| SCHEMBL22453626 | 0.75 | SERPINE1 (0.65) | SERPINE1PGRNPC1HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |