Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31555349 | 1.00 | SERPINE1 (0.51) | SERPINE1GRM1MEN1KMT2AGFER | |
| SCHEMBL22452486 | 0.89 | HIF1A (0.50) | SERPINE1MEN1KMT2AGFERHIF1A | |
| SCHEMBL22452715 | 0.87 | SERPINE1 (0.64) | SERPINE1MEN1KMT2AGFERHIF1A | |
| SCHEMBL22452528 | 0.86 | NPC1 (0.56) | SERPINE1MEN1KMT2AGFERHIF1A | |
| SCHEMBL22452789 | 0.85 | SERPINE1 (0.61) | SERPINE1MEN1KMT2AHIF1AEPAS1 | |
| SCHEMBL22453641 | 0.83 | DHODH (0.55) | SERPINE1MEN1KMT2AHIF1AEPAS1 | |
| SCHEMBL22453415 | 0.82 | SERPINE1 (0.53) | SERPINE1MEN1KMT2AGFERHIF1A | |
| SCHEMBL22453322 | 0.82 | POLB (0.44) | SERPINE1HIF1AEPAS1EPHX2NPC1 | |
| SCHEMBL22452762 | 0.82 | SIRT2 (0.46) | SERPINE1HIF1AEPAS1EPHX2NPC1 | |
| SCHEMBL22452983 | 0.82 | MEN1 (0.48) | SERPINE1MEN1KMT2AHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113811300-A | Novel small molecule inhibitors of TEAD transcription factor | 总医院公司 | 2021-12-17 | — | — | CN | disclosed |
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |