Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 10/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.48 |
| ▸ | MDH1 | P40925 | 2/20 | 0.47 |
| ▸ | MDH2 | P40926 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452688 | 0.90 | HIF1A (0.46) | HIF1AEPAS1MDH1MDH2NPC1 | |
| SCHEMBL22453693 | 0.80 | HIF1A (0.54) | HIF1AEPAS1MDH1MDH2NPC1 | |
| SCHEMBL22453116 | 0.76 | HIF1A (0.47) | HIF1AEPAS1NPC1CYP2C9TP53 | |
| SCHEMBL22453766 | 0.75 | HPGD (0.56) | HIF1AEPAS1NPC1CYP2C9TP53 | |
| SCHEMBL23210638 | 0.74 | HIF1A (0.64) | HIF1AEPAS1MDH1MDH2NPC1 | |
| SCHEMBL22453681 | 0.74 | ELANE (0.56) | HIF1AEPAS1MDH1MDH2NPC1 | |
| SCHEMBL22453221 | 0.73 | HIF1A (0.51) | HIF1AEPAS1MDH1MDH2NPC1 | |
| SCHEMBL22452696 | 0.73 | HIF1A (0.53) | HIF1AEPAS1NPC1CYP2C9RAB9A | |
| SCHEMBL20482054 | 0.73 | HIF1A (0.54) | HIF1AEPAS1MDH1MDH2NPC1 | |
| SCHEMBL22453223 | 0.72 | MAPT (0.57) | P2RX3CYP1A2SMN1; SMN2MAPTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |