Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452757 | 0.83 | EPHX2 (0.49) | EPHX2NPC1LMNAMAPTHIF1A | |
| SCHEMBL22815320 | 0.79 | EPHX2 (0.57) | EPHX2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL22453102 | 0.79 | EPHX2 (0.49) | EPHX2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL31555348 | 0.77 | HIF1A (0.60) | EPHX2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL22452498 | 0.77 | HIF1A (0.60) | EPHX2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL22453281 | 0.77 | HIF1A (0.44) | EPHX2NPC1LMNAMAPTHIF1A | |
| SCHEMBL22452479 | 0.76 | EPHX2 (0.50) | EPHX2NPC1LMNAMAPTHIF1A | |
| SCHEMBL24421748 | 0.75 | EPHX2 (0.53) | EPHX2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL21670815 | 0.75 | EPHX2 (0.53) | EPHX2NPC1LMNAMAPTALDH1A1 | |
| SCHEMBL22161661 | 0.75 | EPHX2 (0.53) | EPHX2NPC1LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |