SCHEMBL22454895

SCHEMBL22454895

N#Cc1ccc2c(c1)c1ccccc1n2-c1c(-n2c3ccccc3c3cc(-c4ccccn4)ccc32)c(-n2c3ccccc3c3cc(-c4ccccn4)ccc32)c(-n2c3ccccc3c3cc(-c4ccccn4)ccc32)c(-n2c3ccccc3c3cc(-c4ccccn4)ccc32)c1-n1c2ccccc2c2cc(-c3ccccn3)ccc21

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 12/20 0.44
TGFBR1 P36897 1/20 0.41
METAP2 P50579 1/20 0.40
METAP1 P53582 1/20 0.40
NPY5R Q15761 1/20 0.40
PTGER4 P35408 2/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
MAPT P10636 1/20 0.39
TSHR P16473 1/20 0.39
HTT P42858 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23343985 0.89 NPY5R (0.43) GRM5TGFBR1METAP2NPY5RKDM4E
SCHEMBL25837041 0.88 NPY5R (0.40) GRM5TGFBR1METAP2NPY5RALDH1A1
SCHEMBL25837042 0.88 NPY5R (0.40) GRM5TGFBR1METAP2NPY5RALDH1A1
SCHEMBL23341614 0.87 KDM4E (0.40) GRM5METAP2METAP1PTGER4KDM4E
SCHEMBL22705237 0.86 GRM5 (0.42) GRM5TGFBR1METAP2METAP1KDM4E
SCHEMBL22705192 0.84 GRM5 (0.42) GRM5TGFBR1METAP2METAP1NPY5R
SCHEMBL23344067 0.83 NPY5R (0.41) GRM5TGFBR1METAP2NPY5RKDM4E
SCHEMBL24513707 0.83 PTGER4 (0.42) PTGER4KDM4EALDH1A1MAPT
SCHEMBL22454865 0.82 FLT3 (0.41) PTGER4
SCHEMBL23296374 0.82 KDM4E (0.43) GRM5METAP2METAP1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020189283-A1 CHARGE-TRANSPORTING COMPOUND AND MANUFACTURING METHOD THEREOF, INK COMPOSITION, ORGANIC ELECTROLUMINESCENCE ELEMENT MATERIAL, ETC. コニカミノルタ株式会社 2020-09-24 WO disclosed