SCHEMBL22454865

SCHEMBL22454865

N#Cc1ccc2c(c1)c1ccccc1n2-c1c(-n2c3ccccc3c3cc(-c4ccncc4)ccc32)c(-n2c3ccccc3c3cc(-c4ccncc4)ccc32)c(-n2c3ccccc3c3cc(-c4ccncc4)ccc32)c(-n2c3ccccc3c3cc(-c4ccncc4)ccc32)c1-n1c2ccccc2c2cc(-c3ccncc3)ccc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 2/20 0.41
PTGER4 P35408 2/20 0.40
CYP11B2 P19099 3/20 0.37
MAPK14 Q16539 3/20 0.37
CYP11B1 P15538 2/20 0.37
CYP17A1 P05093 1/20 0.37
ABCG2 Q9UNQ0 1/20 0.37
CYP19A1 P11511 1/20 0.36
CSNK1A1 P48729 1/20 0.36
CSNK1D P48730 1/20 0.36
SLC6A2 P23975 1/20 0.36
ROCK1 Q13464 2/20 0.36
PKN1 Q16512 1/20 0.36
PKN2 Q16513 1/20 0.36
ROCK2 O75116 1/20 0.36
GSK3A P49840 2/20 0.36
GSK3B P49841 2/20 0.36
MAPK13 O15264 1/20 0.36
RAF1 P04049 1/20 0.36
MAPK12 P53778 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22454866 0.89 PTGER4 (0.40) PTGER4CYP19A1
SCHEMBL23344042 0.88 MAPK14 (0.38) PTGER4CYP11B2MAPK14SLC6A2ROCK1
SCHEMBL19909044 0.88 FLT3 (0.40) FLT3PTGER4CYP11B2MAPK14CYP11B1
SCHEMBL22454896 0.86 CYP11B2 (0.55) FLT3CYP11B2CYP11B1CYP17A1ABCG2
SCHEMBL23979223 0.86 SQOR (0.41) CYP11B2MAPK14ROCK1GSK3AGSK3B
SCHEMBL31272976 0.85 MAPK14 (0.36) FLT3PTGER4CYP11B2MAPK14CYP11B1
SCHEMBL24513707 0.85 PTGER4 (0.42) PTGER4
SCHEMBL31272971 0.84 MAPK14 (0.35) FLT3PTGER4CYP11B2MAPK14CYP11B1
SCHEMBL20923544 0.83 PTGER4 (0.38) FLT3PTGER4CYP11B2MAPK14CYP11B1
SCHEMBL19908925 0.83 MAPK14 (0.39) FLT3PTGER4CYP11B2MAPK14CSNK1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020189283-A1 CHARGE-TRANSPORTING COMPOUND AND MANUFACTURING METHOD THEREOF, INK COMPOSITION, ORGANIC ELECTROLUMINESCENCE ELEMENT MATERIAL, ETC. コニカミノルタ株式会社 2020-09-24 WO disclosed