Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.65 |
| ▸ | CA2 | P00918 | 5/20 | 0.58 |
| ▸ | CA1 | P00915 | 3/20 | 0.58 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248320 | 0.91 | HPGDS (0.54) | HPGDSCA2CA1MMP12C3AR1 | |
| SCHEMBL2245488 | 0.86 | HPGDS (0.71) | HPGDSCA2CA1MMP12CTSB | |
| SCHEMBL2246061 | 0.85 | CA2 (0.69) | HPGDSCA2CA1MMP12C3AR1 | |
| SCHEMBL2245325 | 0.85 | CA2 (0.69) | HPGDSCA2CA1MMP12C3AR1 | |
| SCHEMBL4384045 | 0.81 | CA2 (0.53) | CA2CA1CTSBCTSSKMT2A | |
| SCHEMBL2248627 | 0.81 | CA2 (0.60) | CA2CA1MMP12C3AR1KMT2A | |
| SCHEMBL5260684 | 0.80 | CA2 (0.70) | CA2CA1C3AR1KMT2AMMP2 | |
| SCHEMBL5260686 | 0.80 | CA2 (0.70) | CA2CA1C3AR1KMT2AMMP2 | |
| SCHEMBL2249747 | 0.80 | CA2 (0.63) | CA2CA1MMP12C3AR1KMT2A | |
| SCHEMBL27708431 | 0.80 | CA2 (0.57) | HPGDSCA2CA1MMP12C3AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101223130-A | Glutamate aggrecanase inhibitors | WYETH CORP (US) | 2008-07-16 | — | — | CN | claimed |
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |
| CN-101223130-A | Glutamate aggrecanase inhibitors | WYETH CORP (US) | 2008-07-16 | — | — | CN | disclosed |