Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977958 | 0.93 | XDH (0.54) | XDHMEN1LMNATHRBBLM | |
| SCHEMBL30924956 | 0.93 | XDH (0.54) | XDHMEN1LMNATHRBBLM | |
| SCHEMBL96494 | 0.93 | LMNA (0.57) | XDHMEN1LMNATHRBBLM | |
| Benzene SCHEMBL27923728 | 0.93 | LMNA (0.57) | XDHMEN1LMNATHRBBLM | |
| SCHEMBL30721661 | 0.91 | LMNA (0.55) | XDHMEN1LMNATHRBBLM | |
| Water SCHEMBL28190393 | 0.91 | LMNA (0.55) | XDHMEN1LMNATHRBBLM | |
| SCHEMBL11768743 | 0.90 | LMNA (0.60) | XDHMEN1LMNATHRBBLM | |
| SCHEMBL30497064 | 0.90 | LMNA (0.60) | XDHMEN1LMNATHRBBLM | |
| SCHEMBL5711323 | 0.88 | LMNA (0.57) | XDHMEN1LMNATHRBBLM | |
| SCHEMBL9472294 | 0.85 | MEN1 (0.47) | XDHMEN1LMNATHRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 185 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108658744-B | Azulene aldehyde derivative and preparation method and application thereof | 南京信息工程大学 | 2021-06-01 | — | — | CN | claimed |
| CN-110041246-A | The synthesis and application of novel Kessazulen sesquiterpene alkaloids | 中国海洋大学 | 2019-07-23 | — | — | CN | claimed |
| CN-108658744-A | A kind of Azulene aldehyde derivatives and the preparation method and application thereof | 南京信息工程大学 | 2018-10-16 | — | — | CN | claimed |
| CN-108440528-A | Fourth Ring Bu Luomo structural domain inhibitor | 艾伯维公司 | 2018-08-24 | — | — | CN | claimed |
| CN-105026403-B | Tetracyclic Bromodomain Inhibitors | 艾伯维公司 | 2018-05-18 | — | — | CN | claimed |
| CN-105189504-B | Fused tetracyclic bromodomain inhibitors | 艾伯维公司 | 2017-07-18 | — | — | CN | claimed |
| CN-105189504-A | Fused tetracyclic bromodomain inhibitors | ABBVIE INC | 2015-12-23 | — | — | CN | claimed |
| CN-102256982-B | Process for making a crystalline zilpaterol salt | INTERVET INT BV | 2014-12-10 | — | — | CN | claimed |
| CN-102256982-A | Process for making a crystalline zilpaterol salt | INTERVET INT BV | 2011-11-23 | — | — | CN | claimed |
| US-7714146-B2 | Azulene-oxindole compounds as multiple-kinase inhibitors and useful as anticancer agents | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2010-05-11 | — | — | US | claimed |
| US-20080125590-A1 | Azulene compounds | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2008-05-29 | — | — | US | claimed |
| EP-1918277-A2 | Azulene compounds | Industrial Technology Research Institute (TW) | 2008-05-07 | — | — | EP | claimed |
| CN-1886130-A | Use of 2-thia-dibenzo [ e, h ] azulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders | PLIVA ISTRAZIVACKI INST D O O (HR) | 2006-12-27 | — | — | CN | claimed |
| CN-1649875-A | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | PLIVA D D (HR) | 2005-08-03 | — | — | CN | claimed |
| JP-60104177-A | — | — | None | — | — | JP | disclosed |
| JP-60104179-A | — | — | None | — | — | JP | disclosed |
| CN-112939855-B | Process for preparing 1, 4-dihydropyridine derivatives containing azulene ring structure | 马鞍山市泰博化工科技有限公司 | 2024-03-26 | — | — | CN | disclosed |
| US-4069233-A | Fluoroaliphaticsulfonyl substituted ethylenes substituted by furyl, thenyl, or 1H-pyrrolyl groups | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1978-01-17 | — | — | US | disclosed |
| US-3984357-A | Fluoroaliphaticsulfonyl substituted ethylenes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1976-10-05 | — | — | US | disclosed |
| US-3932526-A | Fluoroaliphaticsulfonyl substituted ethylenes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1976-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125590-A1 | Azulene compounds | AZI2, PRMT5, BRCA1 | XDH 1689/4885MEN1 13/4885LMNA 4141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.