Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROR1 | Q01973 | 1/20 | 0.69 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22465225 | 0.89 | ROR1 (0.63) | ROR1CYP19A1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL22465369 | 0.87 | ROR1 (0.63) | ROR1CYP19A1HDAC3HDAC4HDAC1 | |
| SCHEMBL22465359 | 0.85 | ROR1 (0.61) | ROR1CYP19A1HDAC3HDAC4HDAC1 | |
| SCHEMBL14242303 | 0.84 | ROR1 (0.91) | ROR1CYP19A1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL28320429 | 0.81 | ROR1 (0.68) | ROR1CYP19A1HDAC6KDM4EALDH1A1 | |
| SCHEMBL13708477 | 0.81 | ROR1 (0.82) | ROR1CYP19A1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL22465743 | 0.79 | PDCD1 (0.55) | ROR1CYP19A1HDAC6ALDH1A1CYP3A4 | |
| SCHEMBL16099332 | 0.76 | ROR1 (0.67) | ROR1CYP19A1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL15945904 | 0.76 | ROR1 (0.77) | ROR1CYP19A1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL22465740 | 0.73 | KDM4E (0.49) | ROR1CYP19A1KDM4EALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11479537-B2 | T-type calcium channel inhibitor | KINKI UNIVERSITY (JP) | 2022-10-25 | — | — | US | disclosed |
| US-20200308132-A1 | T-TYPE CALCIUM CHANNEL INHIBITOR | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2020-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11479537-B2 | T-type calcium channel inhibitor | CACNA1H, CACNA1I, CACNA1G | ROR1 1712/4885CYP19A1 4041/4885HDAC3 560/4885 |
| US-20200308132-A1 | T-TYPE CALCIUM CHANNEL INHIBITOR | CACNA1H, CACNA1I, CACNA1G | ROR1 1712/4885CYP19A1 4041/4885HDAC3 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.