Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLCO1B1 | Q9Y6L6 | 3/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29634339 | 1.00 | SLCO1B1 (0.37) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL29869171 | 0.88 | KDM4C (0.35) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL22467487 | 0.88 | KDM4C (0.35) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL21107344 | 0.86 | SLCO1B1 (0.35) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL29869865 | 0.86 | SLCO1B1 (0.35) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL25084462 | 0.85 | SLCO1B1 (0.47) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL21107455 | 0.84 | SLCO1B1 (0.40) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL21107114 | 0.82 | KDM4C (0.34) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL29868781 | 0.82 | KDM4C (0.34) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL29645211 | 0.80 | KDM4C (0.36) | KDM4CNPC1RAB9AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728210-B1 | ISOXAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2026-02-11 | — | — | EP | disclosed |
| EP-3728209-B1 | CYCLOHEXYL ACID ISOXAZOLE AZINES AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2025-12-24 | — | — | EP | disclosed |
| US-12384768-B2 | Isoxazole carboxylic acids as LPA antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-12 | — | — | US | disclosed |
| EP-3986552-B1 | ISOXAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2024-09-18 | — | — | EP | disclosed |
| EP-3728242-B1 | CYCLOHEXYL ACID ISOXAZOLE AZOLES AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2023-03-01 | — | — | EP | disclosed |
| EP-3728242-B1 | CYCLOHEXYL ACID ISOXAZOLE AZOLES AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2023-03-01 | — | — | EP | disclosed |
| US-11447475-B2 | Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-09-20 | — | — | US | disclosed |
| US-20220235040-A1 | ISOXAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2022-07-28 | — | — | US | disclosed |
| CN-114599640-A | Isoxazole carboxylic acids as LPA antagonists | 百时美施贵宝公司 | 2022-06-07 | — | — | CN | disclosed |
| US-11319309-B2 | Cyclohexyl acid isoxazole azines as LPA antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-05-03 | — | — | US | disclosed |
| WO-2020257138-A1 | ISOXAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-12-24 | — | — | WO | disclosed |
| EP-3728210-A1 | ISOXAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2020-10-28 | — | — | EP | disclosed |
| EP-3728209-A1 | CYCLOHEXYL ACID ISOXAZOLE AZINES AS LPA ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2020-10-28 | — | — | EP | disclosed |
| US-20200317656-A1 | CYCLOHEXYL ACID ISOXAZOLE AZINES AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-08 | — | — | US | disclosed |
| US-20200317656-A1 | CYCLOHEXYL ACID ISOXAZOLE AZINES AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-08 | — | — | US | disclosed |
| US-20200317662-A1 | CYCLOHEXYL ACID ISOXAZOLE AZOLES AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-08 | — | — | US | disclosed |
| US-20200317662-A1 | CYCLOHEXYL ACID ISOXAZOLE AZOLES AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-08 | — | — | US | disclosed |
| US-20200308157-A1 | ISOXAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-01 | — | — | US | disclosed |
| US-20200308157-A1 | ISOXAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-01 | — | — | US | disclosed |
| CN-111479807-A | Cyclohexyl acid isoxazoles azines as L PA antagonists | 百时美施贵宝公司 | 2020-07-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11319309-B2 | Cyclohexyl acid isoxazole azines as LPA antagonists | LPAR1, LPAR2, LPAR5 | SLCO1B1 1008/4885KDM4C 4092/4885NPC1 452/4885 |
| US-11447475-B2 | Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists | LPAR1, LPAR2, LPAR5 | SLCO1B1 1123/4885KDM4C 3122/4885NPC1 759/4885 |
| US-20200317662-A1 | CYCLOHEXYL ACID ISOXAZOLE AZOLES AS LPA ANTAGONISTS | LPAR1, LPAR2, LPAR3 | SLCO1B1 724/4885KDM4C 3852/4885NPC1 635/4885 |
| US-20200308157-A1 | ISOXAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | LPAR1, LPAR2, LPAR5 | SLCO1B1 1123/4885KDM4C 3122/4885NPC1 759/4885 |
| US-12384768-B2 | Isoxazole carboxylic acids as LPA antagonists | LPAR3, LPAR1, LPAR5 | SLCO1B1 866/4885KDM4C 3999/4885NPC1 796/4885 |
| US-20200317656-A1 | CYCLOHEXYL ACID ISOXAZOLE AZINES AS LPA ANTAGONISTS | LPAR1, LPAR2, LPAR5 | SLCO1B1 1008/4885KDM4C 4092/4885NPC1 452/4885 |
| US-20220235040-A1 | ISOXAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS | LPAR3, LPAR1, LPAR5 | SLCO1B1 866/4885KDM4C 3999/4885NPC1 796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.