Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLCO1B1 | Q9Y6L6 | 3/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22467484 | 1.00 | SLCO1B1 (0.37) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL29869171 | 0.88 | KDM4C (0.35) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL22467487 | 0.88 | KDM4C (0.35) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL21107344 | 0.86 | SLCO1B1 (0.35) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL29869865 | 0.86 | SLCO1B1 (0.35) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL25084462 | 0.85 | SLCO1B1 (0.47) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL21107455 | 0.84 | SLCO1B1 (0.40) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL21107114 | 0.82 | KDM4C (0.34) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL29868781 | 0.82 | KDM4C (0.34) | SLCO1B1KDM4CNPC1RAB9ALPAR1 | |
| SCHEMBL29645211 | 0.80 | KDM4C (0.36) | KDM4CNPC1RAB9AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111479807-B | Cyclic compounds as LPA antagonists isoxazole azine hexyl acid | 百时美施贵宝公司 | 2024-11-26 | — | — | CN | disclosed |
| CN-114599640-A | Isoxazole carboxylic acids as LPA antagonists | 百时美施贵宝公司 | 2022-06-07 | — | — | CN | disclosed |
| EP-3986552-A1 | ISOXAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2022-04-27 | — | — | EP | disclosed |