Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5494574 | 0.83 | ABL1 (0.48) | ABL1SMYD3MAPK14NPC1RAB9A | |
| SCHEMBL29952772 | 0.82 | ABL1 (0.47) | ABL1SMYD3MAPK14TAS1R3TAS1R1 | |
| SCHEMBL24958916 | 0.78 | ABL1 (0.53) | ABL1MEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL1232191 | 0.77 | KDM1A (0.53) | ABL1SMYD3MEN1CYP1A2CYP2C19 | |
| SCHEMBL22556902 | 0.75 | MMP2 (0.38) | ABL1SMYD3 | |
| SCHEMBL22556900 | 0.75 | MMP2 (0.38) | ABL1SMYD3 | |
| SCHEMBL20934640 | 0.74 | NPC1 (0.39) | NPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL232024 | 0.74 | KDM4E (0.52) | MEN1CYP1A2KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL349519 | 0.74 | KDM4E (0.53) | SMYD3MEN1KMT2AMAPK14RAB9A | |
| SCHEMBL178410 | 0.74 | CNR1 (0.52) | ABL1SMYD3MEN1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198053-A1 | 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-4-METHYLBENZAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS RIPK2 INHIBITORS FOR TREATING E.G. AUTOIMMUNE DISEASES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-10-01 | — | — | WO | disclosed |
| WO-2020198053-A1 | 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-4-METHYLBENZAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS RIPK2 INHIBITORS FOR TREATING E.G. AUTOIMMUNE DISEASES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-10-01 | — | — | WO | disclosed |