Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 4/20 | 0.37 |
| ▸ | FAP | Q12884 | 3/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.37 |
| ▸ | PITRM1 | Q5JRX3 | 2/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16794429 | 0.94 | NAMPT (0.36) | NAMPTPOLBL3MBTL1DPP4FAP | |
| SCHEMBL4780190 | 0.83 | NAMPT (0.41) | NAMPTPOLBL3MBTL1DPP4FAP | |
| SCHEMBL27889764 | 0.83 | NAMPT (0.41) | NAMPTPOLBL3MBTL1DPP4FAP | |
| SCHEMBL27873480 | 0.83 | NAMPT (0.41) | NAMPTPOLBL3MBTL1DPP4FAP | |
| SCHEMBL2830943 | 0.82 | NAMPT (0.40) | NAMPTPOLBL3MBTL1SCD5VNN1 | |
| SCHEMBL5808993 | 0.80 | DPP4 (0.42) | POLBL3MBTL1DPP4FAPDPP8 | |
| SCHEMBL14970428 | 0.80 | NAMPT (0.39) | NAMPTPOLBL3MBTL1DPP4FAP | |
| SCHEMBL31689901 | 0.80 | NAMPT (0.39) | NAMPTPOLBL3MBTL1DPP4FAP | |
| SCHEMBL10075387 | 0.80 | NAMPT (0.39) | NAMPTPOLBL3MBTL1DPP4FAP | |
| SCHEMBL29963899 | 0.80 | VNN1 (0.40) | NAMPTPOLBL3MBTL1DPP4FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3261639-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INT CORPORATION (US) | 2022-08-24 | — | — | EP | claimed |
| EP-3962484-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-03-09 | — | — | EP | disclosed |
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| WO-2020198058-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2020-10-01 | — | — | WO | disclosed |