Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247090 | 1.00 | PDK2 (0.34) | PDK2OPRK1OPRM1OPRL1 | |
| SCHEMBL2236558 | 0.80 | PDK2 (0.41) | PDK2 | |
| SCHEMBL2236550 | 0.80 | PDK2 (0.41) | PDK2 | |
| SCHEMBL1750885 | 0.73 | JAK3 (0.40) | OPRK1OPRM1 | |
| SCHEMBL1587768 | 0.71 | MMP2 (0.35) | — | |
| SCHEMBL2170912 | 0.66 | PDE10A (0.48) | OPRK1 | |
| SCHEMBL2247096 | 0.66 | PDE10A (0.48) | OPRK1 | |
| SCHEMBL16467124 | 0.64 | PDE10A (0.51) | OPRK1 | |
| SCHEMBL3549179 | 0.64 | FFAR4 (0.43) | OPRK1 | |
| SCHEMBL27741477 | 0.63 | OPRK1 (0.39) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346873-A1 | AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010047956-A1 | AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-29 | — | — | WO | disclosed |